Table 2.
Common regions of genomic copy number gain and loss in 64 DLBCL specimens
| Chr, region, and subregion, Mbp | No. clones | Size, Mbp | Max freq, % |
|---|---|---|---|
| Gain | |||
| 1 | |||
| 143.2-256.2 | 94 | 113.0 | 35.9 |
| 149.5-157.3 | 6 | 7.8 | 35.9 |
| 184.6-204.3 | 18 | 19.7 | 29.0 |
| 2 | |||
| 1.9-70.4 | 53 | 68.5 | 21.9 |
| 9.0-56.0 | 30 | 47.0 | 20.3 |
| 59.3-63.9 | 5 | 4.6 | 21.9 |
| 3 | |||
| 0.2-204.6 | 162 | 204.4 | 26.0 |
| 10.9-11.0 | 2 | 0.1 | 24.5 |
| 137.4-188.7 | 48 | 51.3 | 26.0 |
| 5 | |||
| 0-100.6 | 58 | 100.6 | 26.6 |
| 0-0.5 | 2 | 0.5 | 26.6 |
| 107.0-112.5 | 4 | 5.5 | 11.7 |
| 131.4-146.3 | 13 | 14.9 | 14.1 |
| 150.4-158.1 | 7 | 7.7 | 13.5 |
| 171.2-180.7 | 4 | 9.5 | 12.5 |
| 6 | |||
| 0.1-57.1 | 64 | 57.0 | 26.6 |
| 0.1-5.9 | 10 | 5.8 | 26.6 |
| 7 | |||
| 0-158.2 | 134 | 158.2 | 32.8 |
| 0-0.1 | 2 | 0.1 | 32.3 |
| 71.5-73.7 | 8 | 2.2 | 32.0 |
| 136.7-158.2 | 12 | 21.5 | 32.8 |
| 9 | |||
| 0-66.6 | 45 | 66.4 | 16.4 |
| 0-64.9 | 43 | 64.7 | 16.4 |
| 83.9-95.3 | 15 | 11.4 | 12.5 |
| 117.6-134.3 | 22 | 16.7 | 19.5 |
| 122.1-132.8 | 12 | 10.7 | 19.5 |
| 10 | |||
| 102.1-102.9 | 2 | 0.8 | 14.1 |
| 105.5-105.7 | 2 | 0.2 | 12.0 |
| 11 | |||
| 0.8-36.6 | 32 | 35.8 | 14.1 |
| 57.7-134.6 | 79 | 76.9 | 25.8 |
| 61.5-76.8 | 16 | 15.3 | 24.2 |
| 112.0-123.3 | 14 | 11.3 | 25.8 |
| 12 | |||
| 0-133.3 | 126 | 133.3 | 46.1 |
| 0-0.1 | 2 | 0.1 | 46.1 |
| 45.4-53.8 | 9 | 8.4 | 38.4 |
| 13 | |||
| 18.7-52.4 | 36 | 33.7 | 15.6 |
| 70.5-114.0 | 50 | 43.5 | 21.4 |
| 85.0-91.9 | 11 | 6.9 | 21.1 |
| 110.1-114.0 | 9 | 3.9 | 21.4 |
| 16 | |||
| 0.1-31.3 | 29 | 31.2 | 18.8 |
| 0.1-4.7 | 8 | 4.6 | 18.8 |
| 62.4-89.7 | 19 | 27.3 | 17.2 |
| 67.5-89.7 | 16 | 22.2 | 17.2 |
| 17 | |||
| 0.1-84.0 | 75 | 83.9 | 26.0 |
| 39.5-50.1 | 8 | 10.6 | 26.0 |
| 18 | |||
| 4.5-77.6 | 42 | 73.1 | 16.4 |
| 10.0-77.6 | 39 | 67.6 | 16.4 |
| 19 | |||
| 0.2-63.7 | 36 | 63.5 | 18.8 |
| 43.1-63.7 | 17 | 20.6 | 18.8 |
| 20 | |||
| 0.3-4.7 | 9 | 4.4 | 13.3 |
| 22.5-63.6 | 44 | 41.1 | 19.5 |
| 52.0-63.6 | 14 | 11.6 | 19.5 |
| 21 | |||
| 15.1-46.9 | 26 | 31.8 | 17.2 |
| 29.4-46.9 | 13 | 17.5 | 17.2 |
| 22 | |||
| 16.6-49.3 | 33 | 32.7 | 17.3 |
| Loss | |||
| 1 | |||
| 1.0-82.8 | 90 | 81.8 | 25.7 |
| 1.5-9.0 | 10 | 7.5 | 24.2 |
| 78.2-79.1 | 2 | 0.9 | 25.7 |
| 2 | |||
| 2.4-4.1 | 2 | 1.7 | 11.7 |
| 104.2-159.9 | 54 | 55.7 | 15.9 |
| 241.0-241.7 | 2 | 0.7 | 15.6 |
| 4 | |||
| 0-0.7 | 2 | 0.7 | 10.9 |
| 16.1-190.6 | 140 | 174.5 | 27.3 |
| 24.9-34.7 | 7 | 9.8 | 19.5 |
| 178.3-190.6 | 14 | 12.3 | 27.3 |
| 6 | |||
| 62.2-170.5 | 118 | 108.3 | 40.8 |
| 128.7-155.7 | 28 | 27.0 | 40.8 |
| 7 | |||
| 11.7-17.3 | 8 | 5.6 | 12.5 |
| 18.8-19.2 | 8 | 0.4 | 17.2 |
| 18.8-19.2 | 6 | 0.4 | 17.2 |
| 8 | |||
| 0.4-4.0 | 7 | 3.6 | 12.6 |
| 14.9-22.6 | 8 | 7.7 | 11.9 |
| 9 | |||
| 8.3-12.5 | 4 | 4.2 | 15.6 |
| 10 | |||
| 47.0-62.8 | 16 | 15.8 | 19.5 |
| 54.6-58.5 | 6 | 3.9 | 19.5 |
| 107.0-120.0 | 14 | 13.0 | 14.1 |
| 131.5-135.2 | 10 | 3.7 | 14.1 |
| 11 | |||
| 26.7-31.4 | 5 | 4.7 | 10.9 |
| 126.4-134.6 | 12 | 8.2 | 21.2 |
| 130.6-134.6 | 8 | 4.0 | 21.2 |
| 13 | |||
| 35.9-72.8 | 29 | 36.9 | 22.7 |
| 59.4-66.5 | 6 | 7.1 | 22.7 |
| 105.7-106.2 | 2 | 0.5 | 10.9 |
| 14 | |||
| 86.7-105.1 | 18 | 18.4 | 17.2 |
| 90.1-105.1 | 15 | 15.0 | 17.2 |
| 15 | |||
| 20.4-99.7 | 78 | 79.3 | 24.2 |
| 41.2-45.5 | 7 | 4.3 | 24.2 |
| 80.7-99.7 | 20 | 19.0 | 18.8 |
| 16 | |||
| 33.8-35.6 | 2 | 1.8 | 11.2 |
| 61.2-62.4 | 2 | 1.2 | 11.7 |
| 17 | |||
| 0.1-19.8 | 29 | 19.7 | 16.4 |
| 0.1-15.4 | 27 | 15.3 | 16.4 |
| 18 | |||
| 66.2-66.6 | 4 | 0.4 | 12.5 |
| 21 | |||
| 19.3-27.8 | 10 | 8.5 | 13.3 |
Chr indicates chromosome; Max freq, maximum frequency.
Maximum frequency is the average of the frequencies of the 2 most frequent adjacent clones within a region or subregion.