Table 3.
Clinical characteristics of newly diagnosed group 2 MM patients included in survival analysis (n = 67)
| Mayo ID | Sex | Age, y | TC class | Heavy chain | Light chain | 13 del | PCLI | ISS stage | CI | Treatment |
|---|---|---|---|---|---|---|---|---|---|---|
| M025 | F | 49 | D2 | L | Kappa | 0 | 0 | III | 6.19 | BMT |
| M452 | F | 49 | 4p16 | G | Kappa | 1 | 4.2 | I | 5.89 | BMT |
| M413 | M | 54 | 11q13 | L | Lambda | 1 | 4.2 | III | 5.52 | BMT |
| M227 | M | 50 | D1 | L | Kappa | 1 | 0 | I | 5.08 | BMT |
| M263 | F | 53 | 11q13 | L | Kappa | 1 | 6.2 | III | 4.74 | BMT |
| M427 | M | 53 | 11q13 | N | N | 1 | 0 | I | 4.48 | BMT |
| M310 | M | 56 | 4p16 | A | Kappa | 1 | 1.8 | I | 4.15 | BMT |
| M822 | M | 67 | D1 + D2 | A | Lambda | 1 | 2.2 | I | 4.12 | BMT |
| M163 | M | 60 | D1 | A | Kappa | 0 | 0.4 | II | 4.06 | BMT |
| M288 | M | 57 | None | G | Lambda | 0 | 9.4 | II | 5.73 | Dex |
| M196 | F | 68 | MAF | L | Kappa | 1 | 4.4 | — | 5.43 | M + P |
| M814 | M | 67 | MAF | A | Kappa | 1 | 5.2 | III | 4.99 | M + P |
| M037 | M | 81 | D2 | G | Kappa | 1 | 0.2 | III | 4.23 | M + P |
| M024 | M | 81 | 4p16 | G | Kappa | 1 | 3.6 | II | 4.04 | M + P |
| M146 | M | 76 | D2 | L | Kappa | 0 | 1.6 | II | 4.29 | Multiple |
| M318 | M | 51 | D1 | L | Lambda | 0 | 4 | I | 4.52 | Dex |
| M806 | M | 76 | D1 | G | Kappa | 0 | 0 | — | 4.04 | Dex |
| M249 | F | 73 | D1 | A | Kappa | 1 | 5.1 | II | 4.08 | Thal |
| M350 | F | 59 | 6p21 | L | Kappa | — | 0.4 | I | 3.91 | BMT |
| M804 | F | 38 | 11q13 | L | Lambda | 1 | 0 | II | 3.83 | BMT |
| M419 | F | 65 | D2 | A | Lambda | 1 | 0.2 | III | 3.68 | BMT |
| M157 | F | 52 | D2 | L | Lambda | 1 | 0 | I | 3.61 | BMT |
| M200 | M | 65 | D2 | A | Kappa | 0 | 3.8 | II | 3.58 | BMT |
| M380 | F | 51 | D1 | G | Kappa | 0 | 2 | I | 3.57 | BMT |
| M797 | F | 49 | D2 | A | Lambda | 0 | 1.4 | I | 3.47 | BMT |
| M300 | M | 59 | None | G | Kappa | 1 | 1.2 | I | 3.33 | BMT |
| M307 | F | 68 | D1 + D2 | A | lambda | 0 | 0 | III | 3.27 | BMT |
| M058 | M | 70 | D1 | G | lambda | 1 | 0 | III | 3.25 | BMT |
| M198 | M | 53 | D1 | A | Kappa | 0 | 0.4 | II | 3.17 | BMT |
| M387 | F | 62 | D2 | L | Kappa | 0 | 0.2 | II | 3.16 | BMT |
| M407 | M | 58 | D1 | A | Kappa | 0 | 0.6 | I | 3.00 | BMT |
| M700 | M | 59 | D1 | G | Kappa | 1 | 0.8 | I | 2.92 | BMT |
| M687 | M | 62 | D2 | L | lambda | 1 | 0 | I | 2.79 | BMT |
| M059 | M | 61 | D1 | L | Kappa | 0 | 0 | I | 2.79 | BMT |
| M233 | F | 71 | D2 | G | Lambda | 0 | 0.3 | II | 2.74 | BMT |
| M167 | M | 53 | D2 | G | Kappa | 0 | 0.7 | I | 2.64 | BMT |
| M245 | F | 62 | D1 | G | Kappa | 0 | 0 | I | 2.53 | BMT |
| M304 | M | 60 | D1 + D2 | G | Lambda | 0 | 0 | I | 2.53 | BMT |
| M134 | M | 52 | D2 | N | N | 0 | 0 | I | 2.43 | BMT |
| M073 | M | 45 | 11q13 | G | Lambda | 1 | 0 | II | 2.42 | BMT |
| M412 | M | 71 | D1 | G | Kappa | 0 | 0.2 | II | 2.38 | BMT |
| M271 | M | 66 | D2 | A | Kappa | 0 | 0 | II | 2.30 | BMT |
| M410 | F | 64 | None | A | Kappa | 0 | 0 | I | 2.20 | BMT |
| M795 | M | 55 | D1 | G | Lambda | 0 | 0 | II | 2.13 | BMT |
| M373 | M | 53 | D1 | G | lambda | 0 | 0 | I | 2.11 | BMT |
| M338 | F | 45 | D1 | G | Kappa | 0 | 2.8 | II | 1.78 | BMT |
| M678 | M | 70 | 11q13 | A | Kappa | 1 | 0 | II | 1.29 | BMT |
| M467 | M | 44 | D1 | A | Lambda | 0 | 0 | I | 3.82 | Dex |
| M813 | M | 53 | D2 | G | Kappa | 0 | 0.2 | I | 3.60 | Dex |
| M061 | M | 71 | D1 | L | Kappa | 0 | 0 | II | 3.46 | Dex |
| M272 | F | 68 | MAF | L | Lambda | 1 | 1 | III | 3.36 | Dex |
| M356 | M | 74 | MAF | G | Kappa | 1 | 0.6 | I | 2.65 | Dex |
| M264 | F | 56 | D1 | G | Kappa | 1 | 0.6 | III | 2.53 | Dex |
| M032 | M | 78 | D2 | A | Lambda | 0 | 0.2 | II | 3.97 | M + P |
| M218 | F | 69 | D1 | A | Lambda | 0 | 0 | II | 3.94 | M + P |
| M279 | M | 77 | D1 | A | Kappa | 0 | 1.2 | III | 3.57 | M + P |
| M321 | F | 82 | 11q13 | D | Lambda | 1 | 0 | — | 3.35 | M + P |
| M142 | M | 81 | D1 | A | Kappa | 0 | 0.2 | II | 3.20 | M + P |
| M820 | M | 74 | 11q13 | G | Lambda | 1 | 0 | III | 2.84 | M + P |
| M672 | F | 41 | D1 | G | Kappa | 0 | 0 | — | 2.76 | M + P |
| M337 | M | 75 | D1 | A | Kappa | 1 | 0 | II | 2.51 | M + P |
| M135 | M | 78 | D1 | G | Kappa | 0 | 0 | II | 2.33 | M + P |
| M359 | M | 49 | D1 | G | Kappa | 0 | 0.2 | II | 2.06 | M + P |
| M383 | M | 71 | D1 | G | Kappa | 0 | 0.2 | II | 3.74 | Multiple |
| M390 | F | 64 | 11q13 | L | Kappa | 1 | 0.6 | I | 1.59 | Multiple |
| M230 | M | 58 | D1 | A | Kappa | 1 | 1 | III | 2.98 | Multiple |
| M250 | M | 52 | 11q13 | G | Kappa | 1 | 0.8 | II | 2.85 | Thal |
L indicates light chain only; 0, absent; BMT, single autologous stem cell transplantation; G, IgG; I, present; N, nonsecretory MM; A, IgA; Dex, dexamethasone-based treatment; M + P, melphalan and prednisolone; Multiple, multiple nontransplantation-based treatments including novel agents; Thal, thalidomide-based treatment; D, IgD; and —, unknown, due to inadequate information.