Table 1.

Summary of CD34⁺ cell counts and engraftment kinetics of rhesus macaques mobilized with AMD3100 and/or G-CSF

Animal and mobilizing agent	No. of CD34+ cells*	Time to engraftment, d†
RC909	14
AMD3100	3.6 × 106
AMD3100‡	4.8 × 106
RQ2851	7
AMD3100	1.9 × 107
RQ3636	11
AMD3100	2.6 × 107
G-CSF	8.3 × 106
RQ3590	8
AMD3100	4.0 × 106
G-CSF	2.4 × 106
RQ3565§	N/A
AMD3100	1.6 × 107
G-CSF	3.2 × 106
RQ4380§	N/A
AMD3100	1.9 × 107
G-CSF	1.6 × 106

N/A indicates not applicable.

^*Number of CD34⁺ cells per kilogram body weight collected by apheresis after mobilization with AMD3100 or G-CSF

^†Days to reach an absolute neutrophil count greater than 500/μL

^‡Animal RC909 required a second dose of AMD3100 and repeat apheresis 24 hours after the first apheresis to increase the yield of collected PB CD34⁺ cells

^§Animals RQ3565 and RQ4380 did not receive transplants; CD34⁺ cells obtained from these animals were used for in vitro studies only