Table 1.

HCV infection history of the recovered or chronically HCV-infected chimpanzees included in this study

	HCV infection, HCV genotype/treatment
Chimpanzee	Primary infection	First HCV rechallenge	Second rechallenge	Reference
HCV-recovered chimpanzees
Ch1552	1a/IH, cleared after 16 wk	1a/IV, cleared after 4 wk	1a/IV, sterilizing immunity	Nascimbeni et al22; Major et al23
Ch4×0186	1a/IV, cleared after 9 wk	1a/IV, cleared after 6 wk	1b/IV, sterilizing immunity	Nascimbeni et al22; Major et al23
Ch4×0132	1b/IH, cleared after 8 wk	1b/IV, cleared after 10 wk	NA	Thomson et al31,32
Ch1605	1a/IV, cleared after 12 wk	1a/IV, cleared after 3 wk	NA	Nascimbeni et al22; Major et al23
Ch4×0190	1b/IV, cleared after 10 wk	NA	NA	Thomson et al31,32
Ch4×0355	IV, recovered after 9 wk	NA	NA	NA
Ch6455	1a/IV, recovered after 14 wk	NA	NA	Major et al30
Ch6461	1a/IV, recovered after 18 wk	NA	NA	Major et al30
Persistently HCV-infected chimpanzees
Ch6411	1a/IV	NA	NA	Major et al30
Ch6412	1a/IV	NA	NA	Major et al30
Ch6475	1a/IV	NA	NA	Major et al30
Ch1629	1a/IV	NA	NA	Major et al30
Ch1535	1a/IH	NA	NA	Kolykhalov et al33
Ch1536	1a/IH	NA	NA	Kolykhalov et al33

Recovery was defined as absence of detectable serum HCV-RNA by real-time RT-PCR.³⁰,³²,³⁹

IH indicates intrahepatic inoculation; IV, intravenous inoculation; NA, not applicable.