Table 2.
Anti-CCR5 antibody-mediated downregulation of surface CCR5 receptor
| Cells and samples | Mean surface expression of CCR5, % (range) |
|---|---|
| CD4+ lymphocytes | |
| Fetal calf serum | 99 (98-100) |
| HC* | 96 (92-99) |
| LTNP no. 20 | 19 (14-24) |
| LTNP no. 21 | 32 (24-39) |
| LTNP no. 22 | 23 (15-37) |
| RANTES | 45 (41-49) |
| U87-CCR5 | |
| Fetal calf serum | 95 (91-100) |
| HC* | 89 (85-99) |
| LTNP no. 20 | 29 (24-34) |
| LTNP no. 21 | 28 (24-38) |
| LTNP no. 22 | 37 (30-45) |
| RANTES | 54 (52-58) |
Relative percentage of surface expression of CCR5 is expressed as mean of 3 independent experiments with indication of range values.
*
A pool of total purified Ig from 5 healthy control subjects was used as negative control.