Table 1.
Clinical information about patients with T-LGL
| LGL patient no. | Sex | Age, y | Clinical presentation | Abs CD8 | CD4/CD8 ratio | Tg | Spl | Vβ-Jβ restriction | Vβ expansion within CD8, % | Clonal size within Vβ, % | Total clonal size within CD8, % | Addl dx |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 61 | Neutropenia | 1430 | 0.91 | Y | N | Vβ6.7-Jβ2.1 | 51 | 95 | 48.5 | None |
| 2* | M | 63 | Anemia/RCA | 5670 | 0.23 | Y | Y | Vβ17-Jβ2.3 (Vβ3-Jβ2.1) | 45 (25) | 100 (100) | 45 (25) | UC |
| 3* | F | 42 | Neutropenia | 9675 | 0.16 | Y | Y | Vβ20-Jβ2.7 (Vβ20-Jβ2.1) | 25 (25) | 33 (53) | 8.3 (13.3) | Pulm HTN |
| 4 | F | 76 | Anemia/RCA | 5000 | 0.09 | Y | Y | Vβ17-Jβ2.3 | 83 | 100 | 83 | None |
| 5† | M | 46 | Neutropenia | 972 | 1.2 | Y | N | Vβ4 | 10.5 | NA | NA | RA |
| 6 | M | 72 | Neutropenia | 370 | 2.1 | Y | N | Vβ5.3-Jβ2.7 | 27 | 33 | 6.2 | None |
| 7 | M | 53 | Neutropenia/anemia | 4029 | 0.12 | Y | Y | Vβ2-Jβ1.6 | 95 | 100 | 95 | None |
| 8 | F | 77 | Neutropenia | 4480 | 0.11 | Y | Y | Vβ9-Jβ2.5 | 25 | 100 | 25 | RA |
Abs CD8 indicates absolute CD8 count; Tg, T-cell receptor gamma rearrangement; Spl, splenomegaly; Vβ, T-cell receptor variable β chain; Jβ, joining β chain of expanded clonal types; Addl dx, additional diagnoses; RCA, red cell aplasia; UC, ulcerative colitis; Pulm HTN, pulmonary hypertension; NA, not available; RA, rheumatoid arthritis.
*
There were 2 distinct clones for these patients; data in parentheses are for the second clone.
†
This patient had an additional minor clone (Vβ 13.1) detected as well.