Table 5.

Significant variables predictive of outcome on multivariable analysis

	OR/HR	95% CI	P
Complete remission
WBC	0.90*	0.85-0.96	.001
Sex, male	0.58	0.41-0.81	.002
Age	.043
70-79 y	0.93†	0.65-1.34
80 y or older	0.32†	0.13-0.82
Cytogenetics	<.001
Rare aberrations	1.41‡	0.56-3.54
1 or 2 nonrare aberrations	4.80‡	2.91-7.92
Disease-free survival
WBC	1.06*	1.02-1.11	.013
Sex, male	1.29	1.01-1.64	.040
Age	.014
70-79 y	1.17†	0.91-1.50
80 y or older	3.60†	1.66-7.78
Cytogenetics	<.001
Complex ≥5	3.46§	2.07-5.78
Overall survival
WBC	1.05*	1.02-1.08	.002
Sex, male	1.39	1.18-1.65	.001
% marrow blasts	1.06∥	1.01-1.11	.012
Age	.001
70-79 y	1.23†	1.04-1.47
80 y or older	2.04†	1.37-3.06
Cytogenetics	<.001
Complex ≥5	4.49¶	2.85-7.06
Rare aberrations	2.23¶	1.31-3.79
Fewer than 5 non-CBF AML, nonrare aberrations	1.52¶	1.03-2.25

OR indicates odds ratio for complete remission; HR, hazard ratio of relapse and/or death for DFS and OS; and WBC, white blood cell count.

^*OR/HR for a change in WBC of 20 × 10⁹/L.

^†OR/HR are relative to age 60 to 69 years.

^‡OR relative to complex karyotype ≥ 3.

^§HR relative to all other karyotypes.

^∥HR for an increase in bone marrow blasts of 10%.

^¶HR relative to CBF AML group.