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. 2006 Mar 9;108(1):319–327. doi: 10.1182/blood-2005-07-2815

Figure 3.

Figure 3.

Cells expressing BCR/ABL(Y177F) mutant displayed reduced ROS and mutagenic activity. Freshly transformed p190BCR/ABL wild-type (wt) and p190BCR/ABL(Y177F) cells were cultured continuously for 8 weeks in the presence of IL-3. (A) ROS was measured by fluorescence. (B) The percentage of IM-resistant cells (% of IM-resistant cells) was determined by clonogenic assay performed in the absence of IL-3 and the presence or absence of IM. Mutation rate in BCR/ABL kinase is shown. *P = .002 compared with wild-type group.