Table 1.

Markers in the linkage region on chromosome 5 and single-marker LOD scores under a fully penetrant recessive model

			Recombination fraction
Marker	Genetic, cM	Sequence, Mb	0.00	0.01	0.03	0.05	0.10	0.15
D5S2500	69.2	58.7	−∞	−2.83	−1.94	−1.53	−0.97	−0.66
D5S424*	82.0	76.2	2.41	2.35	2.24	2.13	1.85	1.57
D5S2041*	82.0	76.7	1.20	1.17	1.11	1.05	0.90	0.75
D5S1501	85.2	78.5	2.20	2.15	2.04	1.93	1.66	1.39
D5S644	104.8	95.8	2.27	2.23	2.15	2.06	1.83	1.60
D5S2501	117.0	110.0	1.57	1.54	1.47	1.41	1.24	1.07
D5S1505	129.8	119.1	1.32	1.29	1.22	1.16	1.00	0.84
D5S1480	147.5	144.1	−∞	−3.66	−2.34	−1.73	−0.94	−0.54

The 6 rightmost column headings are recombination fractions between the putative disease gene and a marker. Genetic locations are from the Marshfield map.⁴¹

^*Markers were genotyped to prove that AP3B1 (at 77.3 Mb) lay inside the linkage interval.