Table 3.

Presenting features and blast characteristics

	IT MTX, %	ITT, %	Total, %	P
Age	.69
Less than 2 y	9	8	8
2-5 y	69	69	69
6-9 y	22	23	23
Sex	.86
Female	44	44	44
Male	56	56	56
Ethnicity	.66
White	68.6	67.2	67.9
Black	3.9	3.2	3.6
Hispanic	20.8	23	21.9
Asian	1.6	1.3	1.4
Other	5.1	5.4	5.2
Down syndrome	3.2	2.4	2.8	.24
CNS status	.64
CNS-1	93.2	92.1	92.6
CNS-2	5.4	6.1	5.7
CNS-3	1.4	1.8	1.6
TLP+	2	2.5	2.3
WBC count	82	.16
Less than 20 × 109/L	83	81	18
20 × 109/L or above	17	19
Immunophenotype	94.7	.63
B lineage	94.5	95	5.3
T lineage	5.5	5
Triple trisomies*	0.66
Yes	14.2	13.2	13.7
No	85.6	86.8	86.3
TEL/AML1†	.47
Yes	19.2	21.1	20.1
No	80.8	78.9	79.9
BM day 7	.07
M1	49.4	46.7	48
M2	28.2	26.4	27.3
M3	22.4	26.9	24.7
BM day 14	.09
M1‡	92.1	90	91.1
M2	7.9	10	8.9

For IT MTX, n = 1018; for ITT, n = 1009; and for total, n = 2027.

^*881 cases with centrally approved cytogenetics.

^†940 cases analyzed for TEL/AML1.

^‡Includes day 7 M1.