Table 1.

Histopathologic changes of intestine allografts

			Allograft histopathology
Intestine		MLNs
Transplant	No. of recipients	Blood chimerism, day 150, %	No. of apoptosis per 10 crypts	No. of PPs per section	No. of lymphoid nodules per section	Fibrosis grade	Arteritis grade
Normal intestine	4	NA	0.5 ± 0.6	0.30 ± 0.50	1.65 ± 0.42	0	0
Intestine alone	10	0	2.0 ± 1.1	0.03 ± 0.06	0.56 ± 0.50	1.00 ± 1.07	0.20 ± 0.42
Intestine and BM	12	4.2 ± 3.8*	1.2 ± 0.5	0.28 ± 0.21*	1.24 ± 0.47	0*	0*
Irradiated intestine alone	5	0	1.8 ± 0.8	0.02 ± 0.02	0.48 ± 0.32	1.80 ± 0.83	0.20 ± 0.45
Intestine from ALS-pretreated donor alone	7	0	2.0 ± 1.2	0.02 ± 0.05	0.84 ± 0.46	0.86 ± 0.70	0.14 ± 0.24
Irradiated intestine and BM	8	1.9 ± 1.0*	1.3 ± 0.8	0.19 ± 0.16*	1.00 ± 0.36	0*	0*
Intestine from ALS-pretreated donor and BM	11	5.0 ± 3.0*	2.1 ± 0.5	0.20 ± 0.14*	1.12 ± 0.58	0*	0*

BN-to-LEW SITx under TAC 1.0 mg/kg on days 0-13, 20, and 27 after SITx. Data represent mean ± SD.

NA indicates not applicable.

^*P < .05 versus intestine alone (1-way ANOVA and Fisher PLSD).