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Pseudorotational cycle for nucleoside furanose ring puckers. Ring puckers for standard nucleosides are typically either in the ‘Northern’ or ‘Southern’ hemispheres (illustrated by blue cones). Depictions of the N and S conventions along with the structure of an LNA monomer are shown. The pseudorotational positions for the N-MCT and S-MCT analogs are shown on the left half of the wheel.
