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Side-by-side view of (A) T7ST8S (with residues labeled) and (B) the native dodecamer to illustrate the position and potential contacts of the additional atoms in the bicyclo[3.1.0]hexane systems compared to standard furanose rings. Only residues G4-T8 (3′-5′) and C9-A5 (5′-3′) are displayed for clarity. Backbone atoms are cyan; H5′, H5′′ of selected residues are dark blue; carbon and hydrogen atoms of the cyclopropane ring are shown in red and green, respectively.
