Table 2.
Summary of NF-κB requirements in LTβR signaling
|
Gene expression
|
In vivo
|
|||||
|---|---|---|---|---|---|---|
| Genotype | NF-κB complexes activated by LTβR | VCAM ICAM | Ccl21 | Cxcl13 | LN development | T/B zone |
| WT | p50:RelA, p52:RelB, p50:p50 | +++ | +++ | +++ | +++ | + |
| Nfkb1+/–Nfkb2+/– | ND | ND | ND | ND | +++ | + |
| Nfkb1–/– | p52:RelA, p52:RelB | + | + | ++ | ++ | + |
| Nfkb2–/– | p50:RelA, p50:RelB, p50:p50 | – | + | +/– | ++ | + |
| Nfkb1+/–Nfkb2–/– | ND | ND | ND | ND | + | – |
| Nfkb1–/–Nfkb2–/– | – | ND | – | – | – | ND |
ND indicates not detected; +++, full response; ++, intermediate response; +, weak response; –, no response; and +/–, very weak response and elevated basal levels.