Table 2.
Incidence and severity of AOD in d3tx B6AF1 mice that received different numbers of Tregs from donors with or without ovaries
|
AOD in d3tx recipients
|
||||
|---|---|---|---|---|
| Treg donor | Treg donor treatment | Treg nos. | Incidence,% (no.) | Severity* |
| None | – | – | 92 (25) | 8.0 ± 0.8 |
| Female 1 | – | 3 × 104 | 100 (9) | 4.0 ± 1.3 |
| Female 2 | – | 1 × 105 | 44 (9) | 3.7 ± 1.8 |
| Female 3 | – | 3 × 105 | 23 (13) | 2.3 ± 0.6 |
| Female 4 | – | 5 × 105 | 0 (32) | – |
| Male 1 | – | 3 × 104 | 81 (16) | 5.6 ± 1.0 |
| Male 2 | – | 1 × 105 | 45 (11) | 5.4 ± 1.7 |
| Male 3 | – | 3 × 105 | 23 (13) | 1.5 ± 0.3 |
| Male 4 | – | 5 × 105 | 0 (15) | – |
| Female 5 | NOv | 3 × 105 | 55 (11) | 1.0 ± 0.1 |
| Female 6 | NOv | 5 × 105 | 0 (8) | – |
NOv indicates neonatal ovariectomy; –, none.
*
Mean ± SD of mice with disease