Fig. 3.

A superimposition of the N-lobe and C-lobe of apo-hTF illustrating the difference in secondary structure of the region surrounding the hinge residues between the two subdomains of each lobe. In the N-lobe (N1- blue and N2- red), the hinge is adjacent to an anti-parallel β-sheet formed from β-strands e and j. In the C-lobe (C1- green and C2- yellow) the hinge is located within an unstructured region, as β-strand e is shortened and β-strand j is entirely absent. The overlay used SPDBV (90)