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Effect of ligand binding on the oligomeric state of IN. Oligomerization of IN in the presence of various ligands was studied by using analytical gel filtration. The samples were 14 μM IN 1–288 (blue), 14 μM IN 1–288 + 14 μM LEDGF 361–370 (black), 14 μM IN + 14 μM LEDGF 402–411 (red), 14 μM IN 1–288 + 14 μM DNA LTR (green), and 14 μM IN 1–288 + 14 μM DNA LTR + 14 μM LEDGF 361–370 (orange).
