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The shiftide model for IN inhibition. LEDGF-derived peptides are shiftides that shift the oligomerization state of IN toward the tetramer. The LEDGF peptides penetrate the cells and bind IN in the cytoplasm. They shift it to a tetrameric state, reducing its degree of binding to the unprocessed LTR DNA and preventing the 3′ end processing and consequently the strand-transfer catalytic activities.
