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. 2007 May 7;104(20):8427–8432. doi: 10.1073/pnas.0702162104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 1. — Time course and magnitude of HCV-specific T cell immune responses during HCV-LP immunization and after challenge. Four chimpanzees (X0133, X0175, X0199, and X0212) were immunized with HCV-LPs four times over 32 weeks. Arrowheads indicate immunization times, and the arrow indicates the time of HCV-CG1b challenge at week 35 (week 0). (A) IFN-γ response against HCV core, E1/E2, and OLPs. (B) Lymphocyte proliferative responses against HCV core and E1/E2 proteins were assessed over 48 weeks. In each assay, 2 × 10⁵ cells were used. The T cell proliferative response is expressed as stimulation index. (C) IFN-γ responses against HCV nonstructural proteins NS3 helicase, NS4, and NS5A were determined over 48 weeks. NA, not analyzed. SFU, spot-forming unit.

Fig. 1. — Time course and magnitude of HCV-specific T cell immune responses during HCV-LP immunization and after challenge. Four chimpanzees (X0133, X0175, X0199, and X0212) were immunized with HCV-LPs four times over 32 weeks. Arrowheads indicate immunization times, and the arrow indicates the time of HCV-CG1b challenge at week 35 (week 0). (A) IFN-γ response against HCV core, E1/E2, and OLPs. (B) Lymphocyte proliferative responses against HCV core and E1/E2 proteins were assessed over 48 weeks. In each assay, 2 × 10⁵ cells were used. The T cell proliferative response is expressed as stimulation index. (C) IFN-γ responses against HCV nonstructural proteins NS3 helicase, NS4, and NS5A were determined over 48 weeks. NA, not analyzed. SFU, spot-forming unit.