Table 1.
Viremia comparison of naïve and HCV-LP-immunized chimpanzees
| Chimpanzee | Duration of peak viremia, weeks | Peak viremia, units/ml* | AUC,† duration × peak viremia for 52 weeks |
|---|---|---|---|
| HCV-LP | |||
| X0133 | 2 | 3,970 | 7,840 |
| X0175 | 11 | 14,000 | 41,490 |
| X0199 | 10 | 35,400 | 206,140 |
| X0212 | 12 | 54,600 | 295,090 |
| Naïve | |||
| X0142 | >52 | 78,000 | 667,220 |
| X0190 | 13 | 99,000 | 600,000 |
| X0234 | >52 | 200,000 | 497,000 |
| X0140 | >52 | 257,340 | 746,575 |
*Peak viremia; P< 0.029, naïve vs. HCV-LP-immunized animals.
†Area under the curve; P< 0.0016, naïve vs. HCV-LP-immunized animals.