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. 2007 May 2;104(20):8520–8525. doi: 10.1073/pnas.0611364104

Fig. 3.

Fig. 3.

Administration of A-803467 (20 mg/kg, i.v.) significantly reduced von Frey hair-evoked (10 g) (A) and spontaneous spinal dorsal horn WDR neuronal (B) activity. Discharge activity was recorded from 13 WDR neurons located 756.3 ± 71.7 μm from the surface of the spinal cord in L5/L6 spinal nerve-injured rats. Before A-803467 injection, spontaneous WDR firing (first 5 min) was 2.8 ± 0.8 spikes per second, and the baseline evoked response (von Frey hair, 10 g) was 198 ± 32.9 spikes in 15 s. Administration of A-803467 (20 mg/kg, i.v.) reduced both evoked and spontaneous WDR neuron firing by 66.2% and 53.3%, respectively, from baseline levels. The effects of A-803467 were dose-dependent (data not shown). Data shown were collected 35 min after injection. n = 6–7 per group, ∗, P < 0.05 vs. baseline activity.