Fig. 4.

Antiallodynic effects of A-803467 in neuropathic pain. Two weeks after L5-L6 spinal nerve injury (SNL; A) or chronic constriction injury (CCI; B) A-803467 was injected 30 min (i.p.) before testing. A-803467 demonstrated significant antiallodynic effects in both neuropathic pain models [A: F (4, 65) = 21.94, P < 0.0001; B: F (4, 42) = 11.75, P < 0.0001). Circles represent paw withdrawal threshold ipsilateral to the injury; squares represent paw withdrawal threshold contralateral to the injury. Data represent mean ± SEM. ∗∗, P < 0.01 as compared with vehicle-treated animals. (n = 6–12 per group).