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. 2007 May 2;104(20):8520–8525. doi: 10.1073/pnas.0611364104

Fig. 5.

Fig. 5.

Antinociceptive effects of A-803467 in the capsaicin-induced secondary mechanical hypersensitivity and CFA-induced thermal hyperalgesia models. A-803467 was injected 30 min (i.p.) before testing in both assays. (A) A-803467 reversed the secondary mechanical hypersensitivity tested 3 h after intraplantar capsaicin injection [F (4, 43) = 133.9, P < 0.001)]. (B) A-803467 demonstrated significant antihyperalgesic effects when tested 2 days after CFA injection [F (7, 40) = 43.74, P < 0.0001]. Circles represent values ipsilateral to the injury; squares represent values contralateral to the injury. Data represent mean ± SEM. (n = 6–12 per group). ∗, P < 0.05, ∗∗, P < 0.01 as compared with vehicle-treated animals. ++, P < 0.01 as compared with ipsilateral paw.