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. 2007 Apr 5;8(4):R50. doi: 10.1186/gb-2007-8-4-r50

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Copyright © 2007 Tirosh and Barkai; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Properties of duplicates with predicted ancestral or novel functions. Duplicate gene pairs with asymmetric expression divergence are predicted to evolve by neofunctionalization, such that the copy with the higher EC (conserved) retained the ancestral function and the copy with the lower EC (divergent) performs a novel function. The percentage of essential genes, the average normalized sequence divergence [24] and the average normalized expression divergence [25] are shown for the conserved duplicates, divergent duplicates and all duplicates. Error-bars correspond to standard error, calculated by bootstrapping with 1,000 repeats.