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. Author manuscript; available in PMC: 2008 Apr 30.
Published in final edited form as: Neurobiol Learn Mem. 2007 Feb 5;87(4):522–535. doi: 10.1016/j.nlm.2006.12.009

Figure 5.

Figure 5

Susceptibility to LTD-induction is enhanced in aged relative to young adult rats. (A) Illustration of the time course of changes in the slope of the population EPSPs for averaged data from 22 slices obtained from sixteen young adult rats. LFS of the Schaffer collaterals failed to produce an enduring depression of the synaptic response in the test pathway (filled circles) or the control pathway (open circles). (B) Plot of EPSP slopes averaged across 39 slices from thirty-one aged rats. LFS of the test pathway (filled diamonds) produced a depression which was input-specific and not observed for the control pathway (open diamonds). The SEMs are provided for every fifth sweep. The insets illustrate representative waveforms from test (left) and control (right) pathways recorded at the indicated time points before and after LFS.