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. 2007 Jun;14(6):390–399. doi: 10.1101/lm.571007

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Copyright © 2006, Cold Spring Harbor Laboratory Press

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Figure 1. — Induction by a single train of high-frequency stimulation (100 Hz, 1 sec) (HFS) of a long-lasting LTP (L-LTP) instead of a short-lasting LTP (S-LTP) when apamin, an SK channel blocker, was applied during the recovery period but not when it was perfused around the time of LTP induction. (A) Slices were allowed to recover in interface and recordings were also carried out in interface. The figure shows the time course of the fEPSP slope 32 min before and 4 h after LTP induction by a single train (arrow) in the control situation (●) and when apamin was applied during the recovery period (○). (Inset) Sample fEPSP traces from individual experiments are shown; they were recorded just before (a,c) and 4 h after (b,d) the induction stimulation. Traces a and b were recorded in the control situation; c and d were recorded when apamin was applied during recovery. (B) Time course of fEPSP slope 32 min before and 4 h after delivery of 1-sec stimulation train in the control situation (●) and when apamin was applied 15 min before and 15 min after LTP induction (○). (Inset) Labeling similar to that used in A. (Left) A control experiment, (right) an experiment where apamin was applied around LTP induction.