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. 2007 Jun;14(6):390–399. doi: 10.1101/lm.571007

Figure 2.

Figure 2.

Induction of an L-LTP instead of an S-LTP was not caused by apamin when this drug was applied during the whole recording period but was caused by (+)-methyl-laudanosine, another SK channel blocker, when this drug was applied during the recovery period. Contrarily to that induced by apamin, the SK channel blockage caused by (+)-methyl-laudanosine does not resist to a 10-min washout (Scuvée-Moreau et al. 2002; J. Scuvée-Moreau, J.-F. Liégeois, and V. Seutin, unpubl.). (A) Time course of fEPSP slope 32 min before and 4 h after delivery of 1-sec stimulation train in the control situation (●) and when apamin was applied during the whole recording period (○). (Inset) Examples of fEPSP recorded in one experiment just before (a,c) and 4 h after (b,d) induction in the control situation (left) and in presence of apamin (right). (B) Time course of fEPSP slope 32 min before and 4 h after delivery of 1-sec stimulation train in the control situation (●) and when (+)-methyl-laudanosine was applied during the recovery period (○). (Inset) Labeling similar to that used in A. (Left) A control experiment, (right) an experiment where (+)-methyl-laudanosine was applied during the recovery period.