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. 2007 Jun;14(6):390–399. doi: 10.1101/lm.571007

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Copyright © 2006, Cold Spring Harbor Laboratory Press

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Figure 5. — Apamin causes an enhancement of the global depolarization induced by a train of HFS (100 Hz). After recovery and 15 min of baseline recording, apamin was applied for 1 h 15 min. (A,B,C) Each part of the figure compares the first 10 fEPSPs of two series of fEPSPs recorded on a same slice in response to the delivery of one train of HFS, one under the influence of apamin (thick traces), the other before any application of the drug (thin traces). (A) The global depolarization induced by the stimulation train was increased in presence of apamin (here at the 15th min after the start of the apamin perfusion). (B) The global depolarization induced by the stimulation train was still increased 45 min after the end of the application of apamin. (C) The global depolarization was no longer increased when elicited 60 min after the application of apamin had been stopped.