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. 2007 Jun;14(6):390–399. doi: 10.1101/lm.571007

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Copyright © 2006, Cold Spring Harbor Laboratory Press

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Figure 6. — Apamin causes a long-lasting enhancement of the global depolarization elicited by a train of high-frequency stimulation, and this phenomenon is NMDA receptor-dependent. (A,B,C) The amplitude of each of the first 10 fEPSPs within the series of fEPSPs is plotted in function of its rank in the series. (A) Amplitudes of the fEPSPs induced by a stimulation train in a same group of six slices before apamin application, at the 45th min of the drug application, and 45 min after the end of apamin application. (B) Same display as in A, but the stimulation trains were applied on another set of eight slices before, 15 min after the start, and 60 min after the end of apamin perfusion. (C) Same display and same pattern of train delivery on another set of five slices, as in A, but when APV was present throughout the experiment. (D) Illustration of the lack of effect of apamin on the global depolarization induced by a high-frequency stimulation train when APV was coapplied with apamin. The first seven fEPSPs of two series of fEPSPs elicited before (thin trace) and 45 min after apamin application are superimposed.