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. 2007 Jun;14(6):390–399. doi: 10.1101/lm.571007

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Copyright © 2006, Cold Spring Harbor Laboratory Press

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Figure 8. — Apamin did not produce any delayed change in the NMDA receptor-mediated fEPSP. (A) Amplitude of the NMDA receptor-mediated fEPSP in function of the stimulation intensity in the control situation (●) and 20 min after the end of apamin application (○). Apamin was applied for 1 h 15 min. The NMDA receptor-mediated component of the fEPSP was obtained in response to stimulation pulses delivered to the Schaffer collaterals of slices perfused for 20 min with aCSF containing CNQX, a blocker of AMPA receptors. (Inset) Sample trace of an NMDA receptor-mediated fEPSP recorded during an individual experiment. (B) Amplitude of the enhanced NMDA receptor-mediated fEPSP in function of the stimulation intensity in the control situation (●) and 40 min after the end of apamin application (○). After completion of the measurements summarized in A, the same slices were perfused with CNQX dissolved in Mg²⁺-free aCSF. This lifted the Mg²⁺ blockage in the NMDA receptors, so that all the NMDA receptors could be activated by glutamate. (Inset) Sample trace of an enhanced NMDA receptor-mediated fEPSP recorded during the same individual experiment as that shown in the inset of A.