Figure 1.

T-cell reconstitution is incomplete 14 days after BMT. (A) Thymectomized mice received a lethal dose of total body irradiation on day −1 and then were injected with 1 × 10⁶ purified T cells and 5 × 10⁶ BM cells on day 0. (A) On day 14 after BMT, the number of splenic CD3⁺CD8⁺ cells had recovered to 25% of the number detected in thymectomized mice that did not undergo irradiation and BMT (BMT, n = 13; no BMT, n = 8). (B) The number of splenic dendritic cells in mice 14 days after BMT was similar to the number of splenic dendritic cells in mice that had not undergone transplantation (BMT, n = 7; no BMT, n = 8). Dendritic cells were defined as cells expressing H-2 I-A and CD11c. (C) CD44 expression was increased on CD3⁺CD8⁺ cells after BMT (n = 8 mice per group).