Table 1.
Demographics, admission clinical and laboratory data of patients with acute uncomplicated falciparum malaria who were treated with fosmidomycin monotherapy and combination therapy with clindamycin. Data are presented as median (95% C.I.) or number of patients and percentage (n, %) values.
| Characteristics | Fosmidomycin monotherapy (N = 15) | Fosmidomycin + Clindamycin (N = 18) |
| Age (yr) | 36 (19–45) | 29 (18–48) |
| Body weight (kg) | 55 (42–67) | 56 (40–75) |
| Male/Female | 11/4 | 13/5 |
| Ethnic: | ||
| Thai | 5 | 10 |
| Karen | 2 | 3 |
| Burmese | 8 | 5 |
| Body temperature (°C) | 38.3 (36.0–40.0) | 38.0 (37.3–39.9) |
| Baseline asexual form parasitaemia (/μl)a | 11,747 (1,141–173,880) | 30,600 (944–67,640) |
| Haemoglobin (mg/dl) | 12.4 (8.0–15.5) | 12.6 (8.1–15.0) |
| Haematocrit (%) | 38.6 (26.5–44.8) | 39.8 (25.5–45.7) |
| WBC (x109/l) | 5.8 (3.5–8.7) | 6.0 (3.0–8.9) |
| Platelet count (x109/l) | 78 (22–230) | 80 (21–225) |
| Total bilirubin (mg/dl) | 1.5 (0.3–2.5) | 1.3 (0.1–2.6) |
| ALT (IU/l) | 25 (10–98) | 24 (8–103) |
| Creatinine (mg/dl) | 1.2 (0.9–1.8) | 1.1 (0.7–1.9) |
| BUN (mg/dl) | 13 (9–40) | 14 (7–43) |
| Total protein (mg/dl) | 6.2 (5.3–8.1) | 6.0 (5.0–8.0) |
| Albumin (g/dl) | 3.8 (3.0–4.6) | 3.6 (2.9–4.5) |
| Glucose (mg/dl) | 118 (80–198) | 110 (79–205) |
ageometric mean (range)