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. 2007 May 29;404(Pt 3):439–448. doi: 10.1042/BJ20061815

Figure 7. Chemical rescue of the pmt-1 RNAi phenotype with pathway intermediates.

Figure 7

C. elegans L4 hermaphrodites were placed on NGM-agar plates containing bacteria producing GFP dsRNA (A), pmt-1 dsRNA (B), pmt-1 dsRNA plus 10 mM DME (C) or pmt-1 dsRNA plus 30 mM choline (D). Photographs show the phenotype of the F1 progeny four days after introduction of the original L4 to the plate. (A) F1 progeny have developed to the adult stage and many F2 eggs (circle) and some F2 L1 (box) larvae are present. (B) Some F1 progeny have arrested at the L1/L2 stage of development (box) and some have arrested at the L3 stage (circle). F2 eggs and larva are absent. (C, D) F1 progeny have developed to the adult stage, and as in (A), many F2 eggs and some F2 L1 larvae are present.