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. Author manuscript; available in PMC: 2008 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Feb 8;17(8):2216–2219. doi: 10.1016/j.bmcl.2007.01.117

Table 1.

HDAC inhibition by compounds 1a–g, SAHA, and MS-275.

Compounds R IC50, μMa
SAHA 0.090 (± 0.004)
MS-275 3.2 (± 0.1)
1a methyl 134 (± 6)
1b ethyl 449 (± 17)
1c n-propyl 154 (± 7)
1d n-butyl 72 (± 6)
1e allyl 144 (± 9)
1f propargyl 87 (± 5)
1g benzyl 226 (± 11)
a

Values are the means of three experiments with standard error given in parentheses.