Figure 2.

Antibodies to α_vβ₃ and α₂β₁ integrins inhibit rotavirus infectivity additively. Combinations of antibodies directed against different integrins were tested for their ability to block rotavirus infectivity in MA104 cells, as described in the legend for Fig. 1. Data are expressed as percentage of the virus infectivity obtained when the cells were preincubated with MEM as control. The average numbers of foci representing 100% infectivity were 128, 123, and 141 for RRV, nar3, and Wa, respectively. The bars represent the standard error of at least three independent experiments performed in duplicate. The dotted lines at 80% and 100% infectivity are shown for reference. The antibodies used were the same as described in the legend for Fig. 1, except for mAb LM609, which was not used.