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. 2000 Dec 12;97(26):14644–14649. doi: 10.1073/pnas.250299897

Figure 4.

Figure 4

Rotaviruses attach to a site on αvβ3 different from the integrin RGD-recognition domain. MA104 cells were incubated with MEM or peptides GRGDSP (RGD) or GRGESP (RGE) (400 μg/ml) for 60 min at 37°C. The cells were washed and vitronectin (Vn, 1.5 μg/ml) was subsequently added to control (MEM) or peptide-incubated cells for 60 min at 37°C. The cells were then washed and infected with rotaviruses as described in the legend for Fig. 1. Data are expressed as percentage of the virus infectivity obtained when the cells were preincubated with MEM as control. The average numbers of foci representing 100% infectivity were 109, 161, and 114 for RRV, nar3, and Wa, respectively. The bars represent the standard error of at least two independent experiments performed in duplicate.