Table 1.
Behavioral results in Parkinson's disease model
| Animal | Rotations/5
min
|
% change | |
|---|---|---|---|
| Preinfusion | Postinfusion | ||
| TGFα | |||
| 1 | 66.5 | 14.5 | −78.2 |
| 3 | 48.0 | 14.5 | −69.8 |
| 4 | 60.0 | 25.0 | −58.3 |
| 5 | 60.0 | 40.0 | −33.3 |
| 6 | 58.5 | 39.5 | −32.5 |
| 7 | 163.5 | 140.5 | −14.1 |
| 8 | 50.0 | 49.0 | −2.0 |
| 9 | 33.0 | 33.0 | 0.0 |
| 11 | 103.5 | 185.7 | 79.4 |
| Mean | 71.4 | 60.2 | −15.8 |
| SD | 37.2 | 57.1 | |
| aCSF | |||
| 1 | 66.0 | 45.0 | −31.8 |
| 2 | 158.5 | 151.0 | −4.7 |
| 3 | 42.0 | 41.0 | −2.4 |
| 4 | 40.0 | 40.0 | 0.0 |
| 5 | 71.0 | 71.0 | 0.0 |
| 6 | 94.0 | 96.0 | 2.1 |
| 7 | 38.0 | 41.0 | 7.9 |
| 8 | 144.5 | 158.5 | 9.7 |
| 9 | 63.5 | 100.5 | 58.3 |
| 10 | 101.0 | 162.0 | 60.4 |
| 11 | 84.0 | 138.0 | 64.3 |
| Mean | 82.0 | 94.9 | 15.7 |
| SD | 40.4 | 50.5 | |
| t test | (2-tailed) | 0.046 | |
Apomorphine-induced rotations in 6-OHDA-lesioned animals, and 14 days later infused for 14 days with aCSF (control) or TGFα (experimental group). The order of animals is by descending order of % change of rotation. The percent improvement of rotational behavior (three 5-min periods) between the TGFα-treated animals and aCSF-treated animals was 31.5% (significant at P < 0.05, two-tailed t test). The TGFα animals received either 50 or 100 μg TGFα. Animals receiving 10 μg TGFα did not show significant improvement and were not included in this analysis.