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. 2000 Dec 12;97(26):14715–14719. doi: 10.1073/pnas.260491197

Figure 3.

Figure 3

Ultrastructure showing reduced synaptic vesicular docking. After presynaptic injection of the Syt-CM peptide, presynaptic active zones showed the usual set of docked vesicles on, or in tight contact with, the presynaptic membrane (A, C, and D, arrowheads). By contrast, similar presynaptic injection of the Syt-C peptide produced a marked reduction of docked vesicles. In latter case, the clusters of vesicles appear as lingering above the plasmalemma (B, E, and F), resulting in a 10 − 75-nm-wide space empty of vesicles along most of the active zones (arrows). (Bar in A = 1 μm in A and B; bar in F = 0.2 μm in C–F.)