Figure 2.

Impaired hippocampal learning and memory in 5-HT_1A-KO mice as measured by Y maze. (A) Arm entries (Left) and dwell time (Center) of 5-HT_1A-KO (n = 10) and WT (n = 11) mice in Y maze, 1 h after the first encounter with the partially opened maze. The percentage of animals selecting the novel arm as the first choice is shown (Right). (B) Performance of 5-HT_1A-KO (n = 10) and WT (n = 11) mice in the Y maze, 2 min after the first encounter with the maze. ∗ and ∗∗ represent statistically significant differences (P < 0.05 and P < 0.005, respectively; ANOVA followed by Fisher's probable least-squares difference).