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. 2007 Jul 4;2(7):e585. doi: 10.1371/journal.pone.0000585

Figure 5. Mature lymphocytes and DAP12 protect against gonadal failure induced bone loss.

Figure 5

Ovariectomies were performed on 8-week-old Rag1-/- and DKO mice. Four weeks later, both ovariectomized and sham operated animals were sacrificed. (A) Bone mass was assessed by histomorphometric analysis after Von Kossa/Von Gieson staining. (B) The efficiency of ovariectomy was evaluated by weighing the uteri. (C) Results of the quantification show that Rag1-/- mice, as well as KΔ75;Rag1-/- mice, lost more than 50% of their bone mass after ovariectomy. (*** or ††† p<0.0001)