Figure 1.

Example of mammalian genomic alignment showing conserved exonic and intronic sequences. Shown is a small portion of the human gene LMO7 aligned against the orthologous region of the six mammalian genomes used in this study. (A) Four exons (represented as boxes) and their corresponding introns. The central graphic indicates the observed splicing events. Below that, the conservation is represented as a histogram where the height is proportional to the degree of conservation. (B) An expanded view of the sequence flanking the 5′ splice-junction of the second, alternatively spliced, exon. The actual sequence is displayed below the conservation histogram. Boxes are placed around conserved sequences (CSs). The original graphics were drawn using the UCSC Genome Browser (http://genome.ucsc.edu; Kent et al. 2002).