Figure 2.

Oxford Grid (Edwards 1991) of PhyOP orthologs showing Homo–Monodelphis synteny blocks. (A) Genomic Synteny for all Monodelphis and Homo chromosomes. Genes are plotted in consecutive gene order along the Monodelphis chromosomes MDO1-8 and MDOX, and along the Homo chromosomes HSA1-22 and HSAX. One-to-one, one-to-many, many-to-one, and many-to-many Homo-to-Monodelphis orthologs are displayed as red, green, blue, and black dots, respectively. Diagonal lines represent genomic segments with conserved synteny. (B) The syntenic relationships for the ancient region of the Homo X chromosome that is syntenic to the Monodelphis X chromosome, and the more recently derived regions on the short arm of HSAX that are syntenic to MDO4 and MOD7. The circled regions have been placed on MDO4 and MDO7 in the current Monodelphis assembly 3, but FISH analyses map these regions to the Xq arm of MDOX (M. Breen and P. Water, pers. comm.).