Table 1.

Functions of the Chd Family Class of Chromatin Remodelers

Subunit	Organism	Biochemical Activities	In vivo functions
Chd1	Saccharomyces cerevisiae	ATPase activity and relocates nucleosomes [54-56]. Exists as a monomer or dimer [24,54]. Component of SAGA and SLIK complexes and HAT activity [24]. Interacts with H3K4me [24]. Transcription elongation [70,71].	transcriptional repressor [10,54,73]. Interacts with SSRP1 [18]. Transcription elongation [10,18]
	Drosophila melanogaster	ATPase activity [57]	transcriptional activator [46] Interacts with SSRP1 [18] transcription elongation [72]
	Mus musculus	HDAC activity [68]	transcriptional activator [32] transcriptional repressor [68] pre-mRNA splicing events[68]
	Human	Interacts with H3K4me [22,25]
Chd2	Mus musculus		Growth retardation and perinatal lethality of homozygous mutants [47]. Decreased neonatal viability, growth delay, and non- neoplastic lesions [47]
Chd3	Drosophila melanogaster	nucleosome-stimulated ATPase activity and mobilizes nucleosomes [16]
	Human	Component of NURD complex [60-62]
Chd4	Drosophila melanogaster	DNA-dependent, nucleosome-stimulated ATPase activity [59]	lymphocyte differentiation [76] T-cell development [76]
	Human	Component of NURD complex [60-62]. Interacts with HDAC1 [62]
Chd9	Human		osteogenic differentiation [39,53]