TABLE 2.

MULTIVARIABLE ANALYSIS OF ASSOCIATION OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR AND PROTEIN C LEVELS AT 24 HOURS WITH PRIMARY GRAFT DYSFUNCTION

	Protein C		PAI-1
Variable	Odds Ratio (95% CI)	p Value	Odds Ratio (95% CI)	p Value
Unadjusted base model	1.39 (1.14, 1.70)	0.001	1.44 (1.12, 1.76)	< 0.001
Adjusted for
Recipient age	1.39 (1.14, 1.69)	0.001	1.43 (1.17, 1.74)	< 0.001
Recipient sex	1.27 (1.02, 1.59)	0.034	1.33 (1.07, 1.65)	0.010
Recipient diagnosis	1.37 (1.12, 1.68)	0.002	1.48 (1.19, 1.86)	0.001
Recipient race/ethnicity	1.42 (1.15, 1.75)	0.001	1.44 (1.18, 1.76)	< 0.001
Procedure type	1.36 (1.11, 1.67)	0.003	1.38 (1.12, 1.69)	0.001
Cardiopulmonary bypass	1.32 (1.08, 1.63)	0.008	1.39 (1.10, 1.77)	0.006
Total ischemic time	1.39 (1.13, 1.71)	0.002	1.51 (1.22, 1.87)	< 0.001
Pulmonary artery systolic pressure at transplantation	1.30 (1.06, 1.59)	0.028	1.23 (0.96, 1.59)	0.104
Blood (ml) during first 24 h	1.36 (1.11, 1.67)	0.003	1.40 (1.15, 1.72)	0.001
Platelet (ml) during first 24 h	1.35 (1.10, 1.66)	0.005	1.35 (1.10, 1.66)	0.005
Fresh frozen plasma (ml) during first 24 h	1.39 (1.13, 1.71)	0.002	1.37 (1.12, 1.69)	0.003

Definition of abbreviations: CI = confidence interval; PAI-1 = plasminogen activator inhibitor 1.

The reported odds ratios are for the relationship between change in each biomarker and primary graft dysfunction risk, adjusted individually for each confounder variable listed. Odds ratios for protein C are reported for each 10% control decrease in protein C, and for each 50-ng/ml increase in PAI-1.