TABLE 5.
URINE NITRIC OXIDE (CORRECTED AND UNCORRECTED FOR URINE CREATININE) AND IMPROVEMENT IN OTHER CLINICAL OUTCOMES
| Type of Sample | Study Day | Organ-Failure–Free Days (95% CI) | p Value | Ventilator-Free Days (95% CI) | p Value |
|---|---|---|---|---|---|
| Urine NO/Cr | Day 0 | 3.6 (1.7–5.4) | 0.0001 | 2.5 (0.7–4.3) | 0.0059 |
| Urine NO/Cr | Day 3 | 4.4 (2.3–6.4) | < 0.0001 | 2.8 (0.8–4.7) | 0.0056 |
| Urine NO | Day 0 | 6.3 (4.3–8.3) | < 0.0001 | 3.9 (2.0–5.9) | < 0.0001 |
| Urine NO | Day 3 | 6.7 (4.6–8.8) | < 0.0001 | 3.6 (1.6–5.7) | 0.0006 |
Definition of abbreviations: CI = confidence interval; NO/Cr = urine nitric oxide to creatinine ratio.
Linear regression analysis controlling for ventilator group assignment was used to determine mean change in organ-failure–free days and ventilator-free days for each log10 increase in urine NO/Cr levels or urine NO levels.