TABLE 6.

MULTIVARIATE ANALYSIS OF BASELINE URINE NITRIC OXIDE (CORRECTED AND UNCORRECTED FOR URINE CREATININE) AND OUTCOMES IN ACUTE LUNG INJURY

Outcomes	Urine NO/Cr	p Value	Urine NO Alone	p Value
Risk of death, OR (95% CI)	0.43 (0.28–0.66)	0.0001	0.33 (0.20–0.54)	< 0.0001
Mean difference in organ-failure–free days, n (95% CI)	2.7 (0.9–4.5)	0.003	4.2 (2.2–6.2)	< 0.0001
Mean difference in ventilator-free days, n (95% CI)	1.9 (0.1–3.7)	0.03	2.1 (0.1–4.1)	0.04

For definition of abbreviations, see Table 4.

Multivariate analysis included sex, ventilator group assignment, estimated glomerular filtration rate, age, APACHE III score, vasopressor use, and sepsis as primary risk factors for acute lung injury. Risk of death was calculated using logistic regression analysis. Mean differences in organ-failure–free days and ventilator-free days were calculated using linear regression analysis. ORs are per log₁₀ increment in urine NO/Cr or urine NO alone.