TABLE 4.
HERITABILITY ESTIMATES FOR CROSS-SECTIONAL AND LONGITUDINAL MEASURES OF LUNG FUNCTION
Twins and Siblings*
|
All Siblings† (SE)
|
|||
---|---|---|---|---|
All Subjects | ΔF508 Homozygotes | All Subjects | ΔF508 Homozygotes | |
MaxFEV1CF% | 0.68 | 0.86 | 0.68 (0.14)‡ | 0.54 (0.22)§ |
AvgFEV1CF% | 0.54 | 0.80 | 1.00 (no SE)‡ | 0.96 (0.19)‡ |
AdjAvgFEV1CF% | 0.70 | 0.78 | 0.96 (0.14)‡ | 0.89 (0.17)‡ |
EstFEV1%@20yrs | 0.62 | 0.56 | 0.73 (0.19)§ | 0.65 (0.28) |
AdjEstFEV1%@20yrs | 0.82 | 0.76 | 0.83 (0.20)§ | 1.00 (no SE)‡ |
Definition of abbreviations: AdjAvgFEV1CF% = adjusted average cystic fibrosis–specific percentile for FEV1; AdjEstFEV1%@20yrs = adjusted estimated FEV1%pred at 20 years; AvgFEV1CF% = average cystic fibrosis–specific percentile for FEV1; EstFEV1%@20yrs = estimated FEV1%pred at 20 years; MaxFEV1CF% = best cystic fibrosis–specific percentile for FEV1 within the last year of available data.
Heritability estimated by multiplying by 2 the correlation in MZ twins minus the correlation in combined same-sex DZ twin and same-sex siblings with < 3 years' difference in age (30)
Heritability estimated by dividing additive trait variance among related siblings by total trait variance for the entire group of siblings using maximum likelihood estimates as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR) (31). Standard errors for each estimate are shown in parentheses.
p value < 0.0001.
p value < 0.001.