Figure 1.

Course of FEV₁% predicted (FEV₁%pred) after bronchiolitis obliterans syndrome (BOS) onset in lung transplant recipients. FEV₁%pred for the average patient profile adjusted for age, pretransplant diagnosis, time-to-BOS, type of transplant, transplant date, and 6-month pre-BOS relative change in FEV₁ (rapid vs. gradual onset of BOS) is shown. Numbers of patients at the onset of each time interval are displayed at the bottom. The rate of decline of FEV₁%pred changed significantly during the first 2 years after BOS onset (p < 0.0001). The steepest decline was seen in the first 6 months (12% decline; p < 0.0001). The decline between 6 and 12 months was also significant (4% decline; p = 0.01).