TABLE 3.
TREATMENT OUTCOMES OF HIV-INFECTED PATIENTS ACCORDING TO TREATMENT DURATION
| Outcomes | Completed in 6 mo (n) (%) | Completed in > 6 mo (n) (%) | Relative Risk (95% CI) | p Value |
|---|---|---|---|---|
| No. of subjects | 33 | 163 | ||
| Characteristics | ||||
| CD4+ T lymphocyte count ⩾ 200 cells/mm3 (28 missing) | 19/31 (61.3) | 97/137 (70.8) | 0.87 (0.64–1.17) | 0.30 |
| Received ART during tuberculosis therapy | ||||
| HAART | 2 (6.1) | 28 (17.2) | 0.33 (0.07–1.55) | 0.16 |
| Single- or dual-drug ART | 16 (48.5) | 65 (39.9) | 1.15 (0.53–2.51) | 0.73 |
| None | 15 (45.5) | 70 (42.9) | (Reference) | 1.00 |
| Opportunistic infection | 24 (72.7) | 84 (51.5) | 1.41 (1.09–1.82) | 0.03 |
| Cavitary disease | 2 (6.1) | 16 (9.8) | 0.62 (0.15–2.56) | 0.74 |
| Received any directly observed therapy | 21 (63.6) | 128 (78.5) | 0.81 (0.62–1.06) | 0.07 |
| Adherent to drug regimen | 32 (97.0) | 70 (42.9) | 2.26 (1.87–2.72) | < 0.001 |
| Substance abuse | 12 (36.4) | 85 (52.2) | 0.70 (0.43–1.12) | 0.10 |
| Bacteriologic outcomes | ||||
| Weeks to sputum smear negative, mean ± SD | 5.4 ± 4.2 | 5.5 ± 5.7 | 0.93 | |
| Weeks to sputum culture negative, mean ± SD | 5.8 ± 2.5 | 8.9 ± 14.5 | 0.03 | |
| Converted cultures in 8 wk | 21/25 (84.0) | 86/121 (71.1) | 1.18 (0.96–1.45) | 0.18 |
| Outcomes | ||||
| All failures | 0 | 9 (5.5) | 0.25 (0.02–4.26)* | 0.36 |
| All relapses (rate per 100 person-years) | 5 (23.4) | 8 (7.04) | 3.32 (1.09–10.2) | 0.04 |
| Acquired drug resistance | 1 (3.0) | 4 (2.5) | 1.23 (0.14–10.7) | 1.00 |
| Adverse drug reaction to treatment | 1 (3.0) | 36 (22.1) | 0.14 (0.02–0.97) | 0.01 |
| Received therapy intermittently | 7 (21.2) | 43 (26.4) | 0.80 (0.40–1.63) | 0.53 |
| Months of follow-up after treatment completion | ||||
| Mean ± SD | 7.8 ± 5.4 | 8.6 ± 7.1 | 0.55 | |
| Median (range) | 7.6 (0–16.6) | 8.6 (0–34.5) | ||
| Died during follow-up† (rate per 100 person-years) | 9 (38.0) | 37 (30.3) | 1.25 (0.60–2.59) | 0.55 |
| Death due to tuberculosis | 1/9 (11.1) | 2/37 (5.4) | 2.06 (0.21–20.2) | 0.49 |
Definition of abbreviations: ART = antiretroviral therapy; CI = confidence interval; HAART = highly active antiretroviral therapy; HIV = human immunodeficiency virus.
*
Estimated 0.5 for every cell with a zero.
†
Three cases relapsed before death during follow-up.