Figure 3.

Decreased levels of cytokines after treatment in MHV68-infected IFN-γR^−/− mice. (A) IFN-γ, IL-6, and tumor necrosis factor (TNF)-α levels were measured in bronchoalveolar lavage (BAL) fluid from mock and MHV68-infected IFN-γR^−/− mice after treatment with saline solution (SS) or the antiviral agent (AV), which was begun on Day 45 postinfection. Levels of cytokines were determined in a multiplex bead immunoassay on Day 120. (B) IL-5 and IL-13 levels were measured in BAL fluid 120 days postinfection in mock and MHV68-infected IFN-γR^−/− mice treated with saline solution or antiviral agent. Shown are means and SEM (n = 4–10 mice in each group).